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c-di-AMP sodium

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产品名称: c-di-AMP sodium
产品型号: GOY-Y0735
产品展商: 谷研
产品文档: 无相关文档
发布时间:2023-04-11

简单介绍

c-di-AMP sodiumN/A


c-di-AMP sodium  的详细介绍

性能参数

产品名称

c-di-AMP sodium

规格

500μg 1mg

货号

GOY-Y0735

 含量

>98.00%

CAS

N/A

别名

N/A

 

 

化学名

N/A

分子式

C20H24N10O12P2.xNa

分子量

分子 N/A

溶解度

N/A

储存条件

Store at -20°C

General tips

 

用途

仅供科研

价格

电询

详细内容

c-di-AMP (Cyclic diadenylate) sodium signaling is a central factor in many Gram-positive bacteria regulating cell wall synthesis, potassium ion channels, DNA repair, and biofilm formation. c-di-AMP sodium is also essential for cell growth, survival, and virulence of several well-known human pathogenic bacteria including S. aureus, L. monocytogenes, S. pyogenes, and Mycobacterium spp[1].c-di-AMP sodium combines with model antigens, such as OVA or β-Gal, acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[4].

[1]. Fahmi T, et al. c-di-AMP: An Essential Molecule in the Signaling Pathways that Regulate the Viability and Virulenceof Gram-Positive Bacteria. Genes (Basel). 2017 Aug 7;8(8). [2]. Ning H, et al. Recombinant BCG With Bacterial Signaling Molecule Cyclic di-AMP as Endogenous AdjuvantInduces Elevated Immune Responses After Mycobacterium tuberculosis Infection. Front Immunol. 2019 Jul 3;10:1519. [3]. Ebensen T, et al. The Combination Vaccine Adjuvant System Alum/c-di-AMP Results in Quantitative and QualitativeEnhanced Immune Responses Post Immunization. Front Cell Infect Microbiol. 2019 Feb 19;9:31. [4]. Sanchez MV, et al. Intranasal delivery of influenza rNP adjuvanted with c-di-AMP induces strong humoral and cellularimmune responses and provides protection against virus challenge. PLoS One. 2014 Aug 20;9(8):e104824.

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